Effect of Hyzaar on serum uric acid in essential hypertension patients with hyperuricemia

VernacularTitle:二氯沙坦/氢氯噻嗪对原发性高血压合并高尿酸血症患者血尿酸的影响
Author: Jianxiong HUANG
Publication Type:Journal Article
Keywords: Hyzaar; Losartan; Hydrochlorothiazide; Hypertension; Hyperuricemia
From: Chinese Journal of Primary Medicine and Pharmacy 2011;18(8):1059-1060
CountryChina
Language:Chinese
Abstract: Objective To observe the efficacy and safety of Hyzaar on hyperuricemia patients with essential hypertension.Methods 178 patients with essential hypertension and hyperuricemia were randomly divided into control group and observation group with each of 89 cases.Patients in the control group were treated with enalapril, 10 mg qd ,and hydrochlorothiazide, 12.5mg qd.Patients in the observation group were given 1 piece of Hyzaar tablet (5mg losartan and 12.5mg hydrochloride per tablet) per day for a course of 8 weeks.Blood pressure,serum uric acid level before and after the treatment were observed.Results Antihypertensive efficacy of the observation group and control group were 95.5% and 93.3% ,respectively( P > 0.05 ).Serum uric acid level of the observation group was significantly decreased than before treatment( P <0.01 ) ,while the serum uric acid of the control group showed no significant changes.The incidence of dry cough was higher in control group.Conclusion Hyzaar showed good efficacy in decreasing blood pressure and uric acid,and good safety in treating patients with primary hyperuricemia and hypertension.