Intervention effect of montelukast on thymus and activation-regulated chemokine in children with asthma
10.3760/cma.j.issn.1008-6706.2011.08.020
- VernacularTitle:孟鲁司特对哮喘患儿胸腺和活化调节趋化因子的干预作用
- Author:
Weiqun KE
;
Kuihua TAN
;
Xiaojin YANG
;
Yuzhan SHEN
;
Yong XIAO
;
Xiaochi HUANG
- Publication Type:Journal Article
- Keywords:
Asthma;
Montelukast;
TARC;
Pulmonary function;
Child
- From:
Chinese Journal of Primary Medicine and Pharmacy
2011;18(8):1052-1054
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the intervention effect of montelukast on thymus and activation-regulated chemokine(TARC) in the children with asthma.Methods 100 children with asthma were randomly divided into montelukast (LTRA) group ( n = 50) and budesonide (BUD) group ( n = 50), the LTRA group was treated with montelukast, the BUD group was treated with budesonide,50 children without asthma as control group were inhaled NS.Before and after 7 days treatment,the asthma symptoms, FEV1,concentration of TARC were measured.Results Before treatment,the concentration of TARC in asthma group was significantly higher than control group (P < 0.05 ).After treatment, the concentration of TARC in BUD group and LTRA group was significandy decreased( P < 0.05 ), but the difference between these two groups was not significantl( P > 0.05 ), the concentration of TARC in control group was not significantly decreased(P > 0.05 ) ;the symptoms were better after treatment in BUD group and LTRA group,(P <0,05) ,and the pulmonary function was significantly improved after treatment in BUD group and LTRA group ( P < 0.05 ).Conclusion TARC was the important factor in children asthma.Montelukast could block the production of TARC ,and was more convenient and safe for children asthma.
