The comparison observation of carvedilol and metoprolol in treatment patients with chronic heart failure and its effect on TNF-α and IL-6

VernacularTitle:卡维地洛与美托洛尔治疗慢性心力衰竭疗效比较
Author: Guangchun HOU ; Chuanzhi GUO
Publication Type:Journal Article
Keywords: Carvedilol; Metoprolol; Chronic heart failure
From: Chinese Journal of Primary Medicine and Pharmacy 2011;18(8):1043-1045
CountryChina
Language:Chinese
Abstract: Objective To observe the effect of carvedilol and metoprolol in patients with chronic heart failure (CHF) and its effect on TNF-α and IL-6.Methods 94 cases of CHF were randomly classified into carvedilol group with 47 cases and metoprolol group with 47 cases, which were treated with metoprolol and metoprolol,respeetively.The clinical effects and the lovels of TNF-α and IL-6 were compared.Results The clinical effeetive rate in carvedilol group was significantly higher than that in metoprolol group( P < 0.05 ).After treatment, the levels of TNF-α and IL-6 were significantly decreased in both groups (P < 0.05 ).Moreover, the levels of TNF-α and IL-6 in carvedilol group were significantly lower than those in metoprolol group after treatment (P < 0.05).Conclusion Carvedilol in improving clinical effective rate and decreasing the levels of TNF-α and IL-6 was better than metoprolol,whieh played an important role in treatment of CHF.