Correlations between the levels of glycosylated hemoglobin A1c and N-Terminal pro-Brain Natriuretic peptide in aged diabetes mellitus patients with heart failure

VernacularTitle:老年糖尿病并心力衰竭患者糖化血红蛋白与N-末端B型钠尿肽原的相关性研究
Author: Wei ZHENG ; Jiangping WU
Publication Type:Journal Article
Keywords: Diabetes mellitus; Heart failure; Glycosylated hemoglobin A1c; N-Terminal pro-Brain Natriuretic peptide; Aged
From: Chinese Journal of Primary Medicine and Pharmacy 2011;18(7):909-910
CountryChina
Language:Chinese
Abstract: Objective To explore the correlations between the levels of glycosylated hemoglobin A1c (HbA1c)and N-Terminal pro-Brain Natriuretic peptide(NT-proBNP)in aged diabetes mellitus(DM)patients with heart failure(HF).Methods 127 patients diagnosed as DM complicated by HF and detected HbA1c and NT-proBNP when admitted into hospital,were divided into three groups according to the levels of HBA1C as follows:group A,4%≤HbA1c≤6.9%;group B,7%≤HbA1≤7.9%;group C,HbA1c≥8%.The levels of NT-proBNP were measured and compared.Results There was no statistical difference between group A and B(P＞0.05),where as the　levels of NT-proBNP in group C increased significantly than that in group A and B(P＜0.01);In group C,HbA1c was linear positively correlated to NT-proBNP(r=0.558,P＜0.01).Conclusion Aged DM patients complicated by HF,the level of HbA1c between 4%and 7.9%was acceptable.Meawhile,HhA1c should the independent risk prediction factor for aged DM patients complicated by HF,which could be used as the guide to the clinical therapy to improve the prognosis.