Advances in the mechanism of intestinal epithelial cell apoptosis induced by protein phosphatase 2A
10.3760/cma.j.issn.1674-635X.2011.02.009
- VernacularTitle:蛋白磷酸酶2A诱导肠上皮细胞凋亡机制研究进展
- Author:
Chenzhang SHI
;
Huanlong QIN
- Publication Type:Journal Article
- Keywords:
Protein phosphatase 2A;
Intestinal epithelial cell;
Apoptosis
- From:
Chinese Journal of Clinical Nutrition
2011;19(2):108-112
- CountryChina
- Language:Chinese
-
Abstract:
Protein phosphatase 2A(PP2A)is a major Ser/Thr phosphatase involved in sevelral cellular signal transduction pathways.The reversible phosphorylation of proteins is accomplished by opposing activities of kinases and phosphatases.PP2A controls the specific dephosphorylation of thousands of phosphoprotein substrates and thus regulates physiological and biochemical processes of organism.The changes of the physiological activities of PP2A closely relate to apoptosis and regeneration of injured intestinal epithelial cell,and PP2A may be a regulatory factor in balancing the apoptosis and regeneration of intestinal epithehal cell.
