Clinical observation on topiramate combined with sodium valproate in treatment of infantile spasms

VernacularTitle:托吡酯联合丙戊酸钠治疗婴儿痉挛的临床观察
Author: Guangfei YANG
Publication Type:Journal Article
Keywords: Spasms,infant; Topiramate; Sodium valproate
From: Chinese Journal of Primary Medicine and Pharmacy 2011;18(12):1645-1646
CountryChina
Language:Chinese
Abstract: Objective To observe the clinical effects of topiramate combined with sodium valproate in treatment of infantile spasms.Methods 40 children with infantile spasms were randomly divided into control group and treatment group,each group 20 patients.The control group was treated with sodium valproate.The treatment group received topiramate combined with sodium valproate.The two groups were all treated for 3 months.Results The total effective rate and electroencephalogram improvement of the treatment group was 95.0% ,90.0% respectively,and significantly better than those of the control group ( 70.0% , 60.0% respectively ) ( x2 = 4.32,4.80, all P < 0.05 ).Conclusion The therapeutic effect of topiramate combined with sodium valproate in treatment of infantile spasms was good and worthy of being widely used in clinic.