Clinical observation on the effect of tripterygium glycosides combined with prednisone in treatment of 51 children with purpura nephritis

VernacularTitle:雷公藤多苷联合泼尼松治疗紫癜性肾炎51例疗效观察
Author: Yunfang HUANG ; Xun FANG ; Juan HUANG ; Wenli CHEN
Publication Type:Journal Article
Keywords: Purpura nephritis; Tripterygium glycosides; Prednisone
From: Chinese Journal of Primary Medicine and Pharmacy 2011;18(12):1635-1636
CountryChina
Language:Chinese
Abstract: Objective To observe the effect of tripterygium glycosides combined with prednisone in treatment of purpura nephritis.Methods 51 patients with purpura nephritis were selected and treated by tripterygium glycosides (1.5～2.0mg/kg) combined with prednisone(1.5～2.0mg/kg) ,three times every day.The total course was 6 to 9 months.Before and after the treatment, the five indicators of bleeding and coagulation, urine protein, occult blood changes and drug side effects and recurrence after drug withdrawal were observed.Results The high coagulation of the blood was improved,and the renal function of 94.1%children recovered.Only 6 cases had little complication and only 1 case had recrudescence 1 year after leaving hospital.Conclusion Tripterygium glycosides combined with prednisone was effective in treating children with purpura nephritis.