The expression of vascular endotbelial growth factor and matrix metalloproteinase-9 in pancreatic carcinoma and its clinical significance
10.3760/cma.j.issn.1008-6706.2011.12.022
- VernacularTitle:血管内皮生长因子和基质金属蛋白酶9在胰腺癌组织中的表达及其临床意义
- Author:
Lizhi BI
- Publication Type:Journal Article
- Keywords:
Pancreatic carcinoma;
Vascular endothelial growth factor;
Matrix metalloproteinase-9
- From:
Chinese Journal of Primary Medicine and Pharmacy
2011;18(12):1629-1630
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of vascular endothelial growth factor (VEGF) or matrix metalloproteinase-9( MMP-9) in pancreatic carcinoma( PCA) and its clinical significance.Methods The expression of VECF and MMP-9 in 50 PCA tissues and in 20 normal pancreatic tissues were examined by immunohistochemistry.Results The expression of VECF and MMP-9 was higher in PCA than that in its surrounding parenchyma and normal pancreatic parenchyma( x2 = 2.82,2.96, all P < 0.05 ) ; The expression of VEGF and MMP-9 were related to the tumor differentiation,the clinical stage and the lymphnode metastasis.Conclusion VECF and MMP-9 should play important role in the invasion and metastasis of PCA, and had a certain significance for predicting recurrence and metastasis of pancreatic cancer.
