The effect of edaravone on serum level of 8-iso-prostaglandin F2α and prognosis in patients with severe head injury

VernacularTitle:依达拉奉对重度颅脑外伤患者预后及血浆8-表氧前列腺素F2α水平的影响
Author: Chao ZHAO ; Shanling MU ; Yuhai ZHANG ; Yun WANG
Publication Type:Journal Article
Keywords: Craniocerebral trauma; Edaravone; Dinoprost
From: Chinese Journal of Primary Medicine and Pharmacy 2011;18(11):1468-1469
CountryChina
Language:Chinese
Abstract: Objective To explore the effect of edaravone on serum level of 8-iso-PGF2α and prognosis in patients with severe head injury(SHI).Methods 68 patients with SHI were randomly divided into two groups,which were both given conventional treatment,while the treatment group was also given extra injection of edaravone for 14d.8-iso-PGF2α,GCS score and GOS were observed and compared between the two groups respectively.Results The decrease of serum level of 8-iso-PGF2α in treatment group was significantly higher than that of the control group,the GCS score and good outcomes after 3 months was significantly higher than that of the control group after the treatment(P＜0.05).Conclusion Edaravone could reduce the serum level of 8-iso-PGF2α in SHI patients and improve the prognosis.which was woah clinical application.