Investigation on correlation between serum hypersensitivity-CRP and β-cell function in patients with gestational diabetes mellitus
10.3760/cma.j.issn.1008-6706.2011.10.024
- VernacularTitle:妊娠期糖尿病患者血清超敏C反应蛋白与胰岛β细胞功能的相关性研究
- Author:
Danhua LAO
;
Zhijian PAN
;
Jianxian HUANG
;
Shen LIANG
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,gestational;
C-reactive protein;
Insulin resistance
- From:
Chinese Journal of Primary Medicine and Pharmacy
2011;18(10):1345-1347
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlation between serum hs-CRP and β-cell finction in patients with gestational diabetes mellitus(GDM).Methods The levels of hs-CRP in 60 patients with GDM(GDM group)and 30pregnant women with normal glucose tolerance(NGT group)were detected.Insulin resistance was assessed by the homeostasismodel insulin resistance index(HOMA-IR),Insulin secretion by the homeostasis β-cell funetiOn index(HOMA-β).Results The levels of hs-CRP and HOMA-IR were higher in GDM group than in NGT group.There was significant difference between two groups(P＜0.01);HOMA-β was lower in GDM group than in NGT group,there was significant difference between two groups(P＜0.05).The level of hs-CRP was correlated with age,pre-pregnant bodymass-index(BMI),screening BMI,fasting blood glucose(FBG),fasting insulin(Fins),and HOMA-IR(r=0.222,0.649、0.862、0.923、0.935、0.941,P＜0.05 or P＜0.01),but was inversely related with HOMA-β(r=-0.872,P＜0.01).Multiple stepwise regression analysis indicated that HOMA-IR and HOMA-β was the most important effect factors of hs-CRP.Conclusion The level of hs-CRP increased in women with GDM.which was related to insulin resistance(IR)and insulin secretion,and it maybe participate in the pathogenesis of GDM.
