γ-amino butyric acid transporter and epilepsy
10.3760/cma.j.issn.1673-4408.2011.03.018
- VernacularTitle:γ-氨基丁酸转运体与癫(癎)
- Author:
Wentao DONG
- Publication Type:Journal Article
- Keywords:
γ-amino butyric acid transporter;
Epilepsy;
Inhibitor
- From:
International Journal of Pediatrics
2011;38(3):261-263
- CountryChina
- Language:Chinese
-
Abstract:
According to 5 different subtypes of γ-amino butyric acid transporter(GAT)in brain regions and subcellular distribution.GAT1 and GAT3 are closely related with occurrence and development of epilepsy.The abnormal expression of GAT or their function damaged contribute to hyperexcitable neurons In seizures.GABAergic inhibit circuit reduces and the down-regulation of GAT expression,primary up-regulation of GAT expression is a reactive changes or cause of epilepsy.
