Effect of Total Flavonoids of Hippophae Rhamnoides on Contractile Mechanics and Calcium Transfer in Stretched Myocyte
- VernacularTitle:沙棘总黄酮对牵张所致心衰心肌细胞的收缩力学和钙离子转运的影响
- Author:
Zhengrong WANG
;
Ling WANG
;
Huahu YIN
;
Fangju YANG
;
Yunqin GAO
;
Zhujun ZHANG
- Publication Type:Journal Article
- Keywords:
hippophae rhamnoides;
myocyte mechanics;
heart failure;
calcium transient;
myocardial contraction
- From:Space Medicine & Medical Engineering
2000;13(1):6-9
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the role of total flavonoids of hippophae rhamnoides in improving contactile function of stretched cardiac myocyte.Method Flavonoids were given to stretched myocytes which were proved their contractile function decline and then myocyte contractile mechanics characteristics and calcium transfer were measured.Result Flavonoids increased myocyte contractility,as indicated by myocyte shortening,velocity of shortening,peak+dL/dt and peak-dL/dt during shortening,in a concentration-dependent manner (r>0.9,P<0.001),and with no relation to the intracellular calcium transfer in the myocytes.Conclusion Flavonoids of the traditional Chinese drug hippophae rhamnoids is effective in improving the contractile function of stretched cardiac myocyte in low dosage.
