Protective effect of the ethanol extract of vaccinium bracteatum thumb leaf on acute liver injury induced by CC14 in mice

VernacularTitle:乌饭树叶醇提取物对四氯化碳致小鼠急性肝损伤的保护作用
Author: Renyan GONG ; Xifeng LI ; Meng WANG
Publication Type:Journal Article
Keywords: Vaccinium bracteatum thumb leaf; Carbon tetrachloride; Liver injury
From: Chinese Journal of Primary Medicine and Pharmacy 2011;18(6):741-743
CountryChina
Language:Chinese
Abstract: Objective To investigate the protective effect of the ethanol extract of vacciniuin bracteatum thumb leaf on acute liver injury induced by CC14 in mice. Methods Sixty mice were allocated into 6 groups randomly, respectively as the normal control group,the model group,the positive control group,the ethanol extract low,middle and high dose group. Each group had 10 mice. Acute hepatic injury model of mice was made by using CC14. The level of ALT, AST in blood serum and SOD,MDA in hepatic tissue were observed. The hepatic tissue was HE-stained conventionally and observed. Results Acute liver injury in mice could be successfully induced by CC14 ,as demonstrated by increased serum ALT, AST levels and severe histological observations. Pretreatment with the ethanol extract of vaccinium bracteatum thumb leaf indicated its potent protective effects on acute liver injury, as demonstrated by a significant decrease in ALT, AST and MDA. Conclusion The ethanol extract of vaccinium bracteatum thumb leaf had an obviously protective effect on acute liver injury induced by CC14, which could be due to its antioxidative stress effect.