Influence of intravesical chemotherapy combined with hyperthmia on TNF 、IGF in carcinoma of bladder after TURBt
10.3760/cma.j.issn.1008-6706.2011.06.005
- VernacularTitle:膀胱癌术后热灌注化疗对胰岛素样生长因子、肿瘤坏死因子含量的影响
- Author:
Wenyu GONG
;
Jiwei WEI
;
Zhu SHI
- Publication Type:Journal Article
- Keywords:
Carcinoma,transitional cell;
Administration,intravesical;
Hyperthmia
- From:
Chinese Journal of Primary Medicine and Pharmacy
2011;18(6):731-733
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the influence of intravesical chemotherapy combined with hyperthmia on levels of insulin growth factor( IGF) and tumor necrosis factor( TNF) in bladder cancer after operation. Methods 64 cases of transitional cell carcinoma of bladder accepted TURBt were randomly divided into two groups: intravesical chemotherapy combined with hyperthmia group and intravesical chemotherapy group. Levels of ICF and TNF in two weeks before therapy 、two weeks after therapy, four weeks after therapy were tested. Results The IGF levels were (65.97±5.25)μg/L,(49.93±1.98)μg/L,(36.82±1.89)μg/L in intravesical chemotherapy combined with hyperthmia group and(61.87 ±5.41)μg/L, (57.86 ±2. 18) μg/L, (48. 68 ±2. 26) μg/L in intravesical chemotherapy group. The TNF levels were(2.32 ±0. 36)μg/L, (3. 84 ±0. 31) μg/L, (8. 79 ±0. 46)μg/L in intravesical chemotherapy combined with hyperthmia group and(2. 21 ±0. 19)μg/L,(2. 89 ±0.47) μg/L, (3. 87 ±0.61)μg/L in intravesical chemotherapy group. The influence of intravesical chemotherapy with hyperthmia on levels of IGF and TNF were significant than intravesical chemotherap, and the influence degree showed in time-dependent manner (all P ＜ 0. 05 ). Conclusion Intravesical chemotherapy combined with hyperthmia had curative effect in inhibiting the recurrence of tumor after operation.
