Effect of dexmedetomidine on agitation during recovery from sevoflurane anesthesia in children
10.3760/cma.j.issn.0254-1416.2011.02.009
- VernacularTitle:右美托咪啶对七氟醚麻醉患儿麻醉恢复期躁动的影响
- Author:
Xiufeng CAN
;
Yanqing CHEN
;
Conghua ZOU
- Publication Type:Journal Article
- Keywords:
Dxmedetomidine;
Child;
Anesthesia recovery period;
Psychomotor agitation;
Sevoflurane
- From:
Chinese Journal of Anesthesiology
2011;31(2):166-167
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of dexmedetomidine on agitation during recovery from sevoflurane anesthesia in children. Methods Three hundred ASA Ⅰ or Ⅱ children, aged 4-7 yr, weighing 16-30kg, scheduled for elective ear-nose-throat operation under general anesthesia, were randomly divided into 2 groups ( n = 150 each) : control group (group C) and dexmedetomidine group (group D) . Dexmedetomidine 0.5 μg/kg in 20 ml was infused intravenously over 10 min before anesthesia induction in group D, while equal volume of normal Saline was infused in group C. Anesthesia was induced with inhalation of 8 % sevoflurane 5 min after the end of administration . The children were tracheal incubated and mechanically ventilated. Anesthesia was maintained with inhalation of 2 % -3 % sevoflurane. BIS was maintained at 40-60 during operation. The recovery time and agitation within 2 h after operation were recorded. Results There was no significant difference in the recovery time between the two groups ( P > 0.05) . The incidence of agitation was significantly lower in group D than in group C ( P <0.05 ) . Conclusion Dexmedetomidine can reduce the occurrence of agitation during recovery from sevoflurane anesthesia in children.
