The associations of methylenetetrahydrofolate reductase gene C677T and A1298C polymorphisms and ulcerative colitis
10.3760/cma.j.issn.0578-1426.2011.05.005
- VernacularTitle:亚甲基四氢叶酸还原酶基因677和1298位点多态性与溃疡性结肠炎的相关性
- Author:
Changlong XU
;
Xiuqing LIN
;
Deyun LAN
;
Jianzhang WANG
;
Bo ZHENG
;
Zhanxiong XUE
- Publication Type:Journal Article
- Keywords:
Colitis,ulcerative;
Polymorphism,single nucleotide;
Methylenetetrahydrofolate reductase
- From:
Chinese Journal of Internal Medicine
2011;50(5):374-377
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between the genetic polymorphisms of methylenetetrahydrofolate reductase (MTHFR) and ulcerative colitis (UC) of Han ethnic population in Zhejiang, China. Methods Two hundred and seventy-four consecutive patients with UC and 726 healthy controls (HC) were studied. The genetic polymorphisms of MTHFR (C677T and A1298C) were genotyped using PCR-RELP methods. Results The frequencies of variant allele and genotype in MTHFR A1298Cgene were higher in UC patients than in the HC (35.77% vs 29. 96%, P =0. 013; 52. 19% vs 44. 90%,P=0.039; respectively). However, there were no significant discrepancies of the allele and genotype frequencies in the MTHFR C677T gene between the UC patients and the HC (P ＞ 0. 05 ). In addition, the MTHFR 677Tr homozygote, T allele and 677CT/1298AC compound genotype were more prevalent in patients with extensive colitis than in those with distal colitis (37. 66% vs 14. 72% ,P = 0. 0002; 49. 35% vs 32.99% ,P =0. 0004; 29. 87% vs 15.23% ,P =0. 006; respectively). Furthermore,the variant allele in the MTHFR A1298C gene (C) in severe UC patients was significantly lower than in mild and moderate UC patients (18.97% vs 33. 88% ,P =0. 022). Conclusion The genetic polymorphisms of MTHFR C677T and A1298C are obviously associated with Han ethnic population with UC in Zhejiang province.
