Effect of icariside Ⅱ on the expression of osteoprotegerin in mouse osteoblasts
10.3760/cma.j.issn.1000-6699.2011.04.020
- VernacularTitle:淫羊藿次甙Ⅱ对小鼠成骨细胞护骨素表达的影响
- Author:
Jingji WANG
;
Zikuan GUO
;
Daohui SONG
;
Dong WU
;
Yongxiang WU
;
Shangquan LIU
- Publication Type:Journal Article
- Keywords:
Icariside Ⅱ;
Obsteoblasts;
Osteoprotegerin
- From:
Chinese Journal of Endocrinology and Metabolism
2011;27(4):337-338
- CountryChina
- Language:Chinese
-
Abstract:
To explore the effect of icariside ? on osteoprotegerin(OPG) expression in osteoblasts, primary osteoblasts were cultured with different concentration of icariside ? and 17?estradiol. As a major metabolite of icarrin in vivo, icariside ? exerted a better effect on OPG expression which plays a key role in osteoporosis. 20 ng/dl icariside ? also exerted better effect on OPG secretion than that of positive control group. Consequently, icariside ?could be a candidate for osteoporosis treatment.
