Transactivation of thyroid hormone receptor βΔ on target genes through thyroid hormone responsive element
10.3760/cma.j.issn.1000-6699.2011.04.019
- VernacularTitle:甲状腺激素受体βΔ通过甲状腺激素反应元件增强靶基因转录的研究
- Author:
Wei XIE
;
Ronglan ZHAO
;
Ying ZHANG
;
Aijun ZUO
;
Dongchun LIANG
;
Bei SUN
;
Gang GUO
;
Jingyu ZHANG
- Publication Type:Journal Article
- Keywords:
Thyroid hormone receptor βΔ isoform;
Thyroid hormone response element;
Enhancer
- From:
Chinese Journal of Endocrinology and Metabolism
2011;27(4):335-336
- CountryChina
- Language:Chinese
-
Abstract:
To study the transactivation of a novel thyroid hormone receptor isoform, TR?. pcDNA3. 1-TR? and pGL3-Promoter/thyroid hormone responsive element were co-transfected into COS-7 cells. The expression of reporter gene was detected. It could be increased up to 45 times by T3. TR? and showed the characteristics of a transcription factor.
