Association between linear growth patterns with serum insulin levels in pre-pubertal children born small for gestational age
10.3760/cma.j.issn.1000-6699.2011.04.005
- VernacularTitle:小于胎龄儿青春前期线性生长方式与血清胰岛素水平关系的研究
- Author:
Hongzhu DENG
;
Minlian DU
;
Yanhong LI
;
Zhe SU
;
Huamei MA
;
Hongshan CHEN
- Publication Type:Journal Article
- Keywords:
Catch-up growth;
Insulin resistance;
Small for gestational age
- From:
Chinese Journal of Endocrinology and Metabolism
2011;27(4):296-300
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the association between two different linear growth patterns with the levels of serum insulin in children bem small for gestational age(SGA).Methods Serum fasting glucose,fasting insulin,and insulin-like growth factor-I(IGF-I)concentrations were determined in 30 catch-up growth(CUG)children bern SGA [CUG-SGA,16 females,14males,(6.62±0.66)year],37 non-catch-up growth(NCUG)children born SGA[NCUG-SGA,15 females,22 males,(5.97±0.56)year],and42 appropriate for gestational age(AGA)children with normal height[AGA,16females,26males,(7.05±0.39)year].Results (1) Basal fasting insulin and homeostasis model assessment for insulin resistance(HOMA-IR)were significantly higher in CUG-SGA group than in NCUG-SGA and AGA group(P<0.01 or P<0.05).But there was no difference in fasting insulin between NCUG-SGA group and AGA group.IGF-I levels in CUG-SGA were significantly higher than in NCUG-SGA group[(212.61±17.81 vs 137.40±14.66)ng/ml,P=0.001],but showed no difference from AGA group(P=0.095).(2)In the SGA group,HOMA-IR showed positive correlation with age,△height SDS,and current body mass index.Fasting insulin showed positive correlation with △height SDS(r=0.500,P=0.002)in≤6 year group as well as with △weight SDS(r=0.496,P=0.030)in>6 year group.Conclusions Insulin as a growth factor may participate in postnatal catch-up growth accompanied with increased insulin resistance in SGA children.
