Notion to the significance of somatotropic axis, gonadal hormones with their post receptor signaling for growth modulating, and relevant treatment during adolescence with growth disorders
10.3760/cma.j.issn.1000-6699.2011.04.001
- VernacularTitle:关注生长激素轴和性激素及其受体后信号对青春期生长调控和相关治疗的意义
- Author:
Minlian DU
- Publication Type:Journal Article
- Keywords:
Puberty growth;
Adult height;
Somatotropic axis;
Gonadal hormones;
Post-receptor signaling
- From:
Chinese Journal of Endocrinology and Metabolism
2011;27(4):277-282
- CountryChina
- Language:Chinese
-
Abstract:
It is well known that a decline secular trend evaluated in the age of puberty onset.Sexual characteristics and linear growth spurt are two major events for puberty.The growth pattern of puberty characterized as acceleration-deceleration-cessation in growth velocity is specific for human being.It is modulated symphonically by both gonadal and somatotropic axes.This article reviews the advances in the modulming mechanisms of pubertal growth,particularly in the local sites of growth plate,and the concept of keeping positive balance between skeletal lineal growth and maturation.Finally,various therapeutic strategies for improving the final adult height in individuals with growth disorders during adolescence are discussed.
