Clinical effect of intracuronary infusion of autologous bone marrow-derived stem cells transplantation in patients with acute myocardial infarction: a recta-analysis
10.3760/cma.j.issn.1671-7368.2011.06.024
- VernacularTitle:经冠状动脉自体骨髓干细胞移植对急性心肌梗死患者临床疗效的荟萃分析
- Author:
Yigang QIU
;
Jing LI
;
Yuxing FEI
- Publication Type:Journal Article
- Keywords:
Myocardial infarction;
Stem cell transplantation
- From:
Chinese Journal of General Practitioners
2011;10(6):435-437
- CountryChina
- Language:Chinese
-
Abstract:
Full text of literatures on randomized clinical trials (RCTs) of intracoronary infusion of autologous bone marrow-derived stem cells (BMSCs) transplantation in patients with acute myocardial infarction (AMI) published at home and abroad were systematically retrieved and reviewed from PubMed database and the China Full Text Journal database to assess its efficacy and safety. Fifteen RCTs were included in a recta-analysis with RevMan version 5. 0 software after strict and standard screening. Results showed that global left ventricular ejection fraction (LVEF) in the patients with BMSCs transplantation improved significantly ( P < 0. 01 ), but no obvious change in their left ventricular end-diastolic volume (LVESV) was observed. Occurrence of end-stage cardiovascular events also decreases significantly ( OR =0. 51, 95% CI =0. 36-0. 72) in patients with AMI.
