Aspirin can reduce serum C reactive protein level in maintenance hemodialysis patients
10.3760/cma.j.issn.1001-7097.2011.04.011
- VernacularTitle:阿司匹林能降低血液透析患者血清C反应蛋白水平
- Author:
Yanling HUANG
;
Yihong ZHONG
;
Xiaoqiang DING
;
Jianzhou ZHOU
;
Jie TENG
;
Zhonghua LIU
;
Yimei WANG
;
Bo SHEN
- Publication Type:Journal Article
- Keywords:
Hemodialysis;
Aspirin;
Arteriovenous fistula;
Embolism
- From:
Chinese Journal of Nephrology
2011;27(4):271-275
- CountryChina
- Language:Chinese
-
Abstract:
Objective To identify the efficacy and safety of aspirin in reducing the serum high sensitivity C reactive protein(hsCRP)level and preventing the internal arteriovenous fistulas(AVF)embolism in maintenance hemodialysis patients. Methods One hundred and ten hemodialysis patients using AVF more than 3 months were randomly divided into 2 groups,the intervention group(n=55,received aspirin 100 mg/d)and the control group(n=55).Examinations were performed at baseline and 6-month after treatment.Serum hsCRP level,platelet aggregates ratio(PAR),coagulation and inflammation indicators were measured.AVF embolism and the adverse events were monitored. Results Six months later.PAR and hsCRP level of the intervention group patients aged≤60 years decreased significantly [(68.14±8.45)%vs (82.37±9.12)%;(4.79±4.81)mg/L vs(6.94±10.26)mg/L,all P＜0.05],and were significantly lower as compared to.the control group[(68.14±8.45)%vs(74.7±11.50)%,(4.79±4.81)mg/L vs(5.12±9.25)mg/L,all P＜0.05].There were 2 cases of AVF embolism occured in both groups,which showed no statistical difierence (P=0.676).The incidence of adverse effeets was higher in the intervention group than that in the control group but no statistical significance was found (20.0%vs 7.2%,P=0.052),while the mortality rate had no difference between 2 groups (3.6%vs 0,P=0.495).Conclusion Use of aspirin 100 mg/d for 6 months can significantly reduce the serum hsCRP level and PAR in hemodialysis patients under 60-year-old without serious adverse reactions.
