Influence of interferon-α therapy on CD8 T memory subsets in patients with chronic hepatitis B
10.3760/cma.j.issn.0254-5101.2011.03.016
- VernacularTitle:IFN-α治疗慢性乙型肝炎疗效与记忆性T细胞的相关性
- Author:
Daojie LIU
;
Peiling DONG
;
Huiguo DING
;
Jingjing ZHAO
;
Juan LI
;
Qingkua MENG
;
Li YAN
;
Bin SUN
;
Yanning WU
;
Yanjun WANG
- Publication Type:Journal Article
- Keywords:
Memory T cell;
Chronic hepatitis B;
IFN-α
- From:Chinese Journal of Microbiology and Immunology
2011;(3):265-268
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influence of interferon-a therapy on CD8 T memory subsets in patients with chronic hepatitis B(CHB) and correlation between the effect of IFN-α and CD8 T memory subsets. Methods Blood samples from 57 patients with CHB were collected before treatment (0 week), at 12 weeks and 24 weeks of treatment with pegylated IFN-α. Assays were performed on freshly isolated peripheral blood mononuclear cells ( PBMCs). For phenotype analysis, All data were acquired on a flow cytometer instrument and prepared for analysis. Results A significantly higher frequency of CD8+ TEM and lower frequency of CD8+ TCM in inactive HBsAg carriers than that in CHB patients prior to treatment was observed (P <0.05). The proportion of CD8 + TCM was higher in group nonresponders than in group respond-ers, and the proportion of CD8 + TEM was lower in group nonresponders than in group responders (P < 0.05 ). The average dosage of IFN-α applied to patients with response was significantly higher than nonresponders. Conclusion The dominance of circulating effector memory T cells may be associated with elimination of viral infection, and possibly benefit for response to therapy with IFN-α.
