Suppression of invasion and migration by 7-hydroxystaurosporine(UCN-01),a new anti-tumor agent
- VernacularTitle:新的抗肿瘤药7-hydroxystaurosporine(UCN-01)抑制肿瘤浸润和转移
- Author:
Qinghui MENG
;
Rongguang SHAO
;
Jingwen XU
;
Saijun FAN
- Publication Type:Journal Article
- Keywords:
7-hydroxystaurosporine(UCN-01);
prostate;
tumor;
invasion;
migration
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2000;5(4):289-294
- CountryChina
- Language:Chinese
-
Abstract:
Aim and Methods To investigate the effect of UCN-01(7-hydroxystaurosporine) on cell migration and invasion ability of DU-145, an invasive human prostate cancer cell line.Results It was found that UCN-01 at non-cytotoxic doses (100 nmol· L-1) significantly inhibited prostate cancer DU-145 cell invasion and migration behaviors.Moreover, this anti-invasion and migration activity of UCN-01 was associated with an up-regulation of cell adhesion molecule E-cadherin. Conclusion These results indicate for first time that UCN-01 inhibits the invasion and migration of human prostate cancer cells.Thus, clinical application of UCN-01 may contribute to the potential benefit for suppression of prostate cancer invasion and metastasis.
