Effect of Gancyclovir on Proliferation and Differentiation of Chronic MyeloidLeukemia Cells and Research of Its Mechanism
- VernacularTitle:更昔洛韦对慢性粒细胞白血病细胞生长和分化影响及其机制研究
- Author:
Xiaoping JU
;
Fang XIA
;
Hong ZHOU
;
Jianzen WANG
;
Zhengxia HUANG
;
Youzhong YUAN
;
Jianmin WANG
- Publication Type:Journal Article
- Keywords:
gancyelovir;
chronic myeloid leukemia;
proliferation;
differentiation
- From:
Chinese Journal of Cancer Biotherapy
2000;7(4):265-268
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore whether gancyclovir (GCV) can inhibit the proliferation and induce the erythro-differ-entiation of the K562 human myeloid leukemia cell line. Methods: 562 cells were cultured with GCV for 4 days to detect cellular changes cloning efficiency, benzidine-positive rate, flow eytometry analysis, and telomerase activity. Results: When 562 cells grew in the medium containing GCV, the cellular growth and division were gradually suppressed,growth fracture decreased and further differentiation towards the cell producing hemoglobins was found. Conclusion: GCVcan inhibit proliferation and induce erythro-differentiation of K562 cells.
