Cytotoxicity of GS and IL-2 Activated PBMC to Malignant Glioma Cells
- VernacularTitle:人参皂甙与IL-2协同诱导PBMC对恶性脑胶质瘤细胞杀伤活性研究
- Author:
Junsheng LUO
;
Lixue GU
;
Huanjiu XI
;
Bingjie WEI
;
Xingbo LIU
;
Jianwu QIU
;
Pengfei ZHANG
;
Hongren SHAN
- Publication Type:Journal Article
- Keywords:
ginsenoside;
IL-2;
BT325;
eytotoxicity
- From:
Chinese Journal of Cancer Biotherapy
2000;7(4):273-274
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate a new method for improving the therapeutic effect on malignant glioma. Methods: A new type of killer cells, named GS-LAK, was induced by means of costimulating the peripheral ginsenoside(GS) and interleukin-2 (IL-2). Comparing with control group-LAK cells, cytotoxicity of GS-LAK cells against malignant glioma cells(BT325) was examined with MTI method. Results: It showed that GS-LAK cells exhibited some advantages over LAKcells in proliferation, cytotoxicity, as well as the utilizing of IL-2. Conclusion: The application of GS-LAK cells mightopen a new prospect to clinical therapeutic approach to malignant glioma.
