In Vitro-in situ Correlation of Propafenone Transnasal Absorption
- VernacularTitle:普罗帕酮鼻黏膜给药研究体外法与在体法的相关性
- Author:
Xiaoling FANG
;
Xiang LU
;
Xiaojun WANG
;
Zhiping LI
;
Nianzhu XI
- Publication Type:Journal Article
- Keywords:
propafenone;
transnasal absorption;
in vitro;
in situ;
correlation
- From:
Fudan University Journal of Medical Sciences
2000;27(3):168-170
- CountryChina
- Language:Chinese
-
Abstract:
Purpose This paper was to investigate the correlation between in vitro and in situ methods for propafenone transnasal absorption.MethodsUsing excised sheep nasal mucosa permeation test in vitro and rat nasal infusion test in situ. By means of changing the medium pH, drug conoentration, and forming β-cyclodextrin inclusion compound, the permeability coeffident (Pm), mean permeation rate, and permeation fraction were determined in vitro. Under the corresponding conditions the absorption rate oostant(k ) ,mean absorption rate and absorption fraction in situ were also detrmined.ResultsThe linear regression coefficient indicated that,under the various experimental conditions,a good in vitro-in situ correlation could be confirmed.ConclusionsHaving an in vitro-in situ correlation is useful for scientific justifying the different methods for nasal absorption studies.
