Effect of Gasoline on the Extracellular Matrix of Dermis in Rat
- VernacularTitle:溶剂汽油经皮染毒对大鼠真皮层细胞间质的影响
- Author:
Peifang QIU
;
Shanlian HU
;
Jinsheng FA
;
Huayin TAO
;
Shiling REN
;
Hongdi SUN
;
Xiaohua YING
- Publication Type:Journal Article
- Keywords:
gasoline;
dermatotoxicology;
collagen;
elastin;
glycosaminoglycan
- From:
Fudan University Journal of Medical Sciences
2000;27(3):189-191
- CountryChina
- Language:Chinese
-
Abstract:
PurposeTo study the effect of gasoline on the extracellular matrix of dermis in rat. Methods45 male Wistar rats were divided into control group, 3 different exposure level groups, which were exposed to gasoline on 2 cm× 3 cm skin area with the dose of 250 mg/cm2 for 1 (group A) ,4(group B)and 8 days (group C) respectively,and an intervention group exposed to 250 mg/cm2 × 8 days gasoline after the application of protective agent on skin. After the treatment, collagen, elastin and glycosaminoglycan (GAG) were assayed in skin departed from intoxicated area.ResultsCompared with control group, collagen was decreased in group C(P<0.05); elastin was decreased in group B and C (P<0.05); glycosaminoglycan was decreased in all exposure groups and intervention group ( P < 0.05 or P < 0.01 )。 Collagen, elastin and glycosaminoglycan(GAG) were significantly lower in group C than in intervention group ( P < 0.05 ). ConclusionsThe extracellular matrix of dermis,including collagen,elastin and GAG were decreased in rat dermal exposed to gasoline.
