EFFECT OF DA ON GABA-ACTIVATED CURRENT IN RAT DRG NEURONS
- VernacularTitle:多巴胺对大鼠背根神经节神经元GABA-激活电流的影响
- Author:
Qin LI
;
Ming YANG
;
Zhiwang LI
- Publication Type:Journal Article
- Keywords:
dopamine-receptor;
GABAA-receptor;
whole-cell patch-clamp recording;
dorsal root ganglion;
rat
- From:
Chinese Journal of Neuroanatomy
2000;16(3):205-208
- CountryChina
- Language:Chinese
-
Abstract:
Whole-cell patch-clamp technique was performed on isolated rat DRG neurons to investigate the modulation of DA onGABA-activated membrane currents. It was found that majority of the examined neurons(40/47) were sensitive to GABA, 10-6～ 103mol/L GABA activated a dose-dependent inward current which had an obvious desensitization. In 26 of 40 neurons sensitiveto GABA DA induced a little outward current which had no desentization at all. Others showed no effect obviously. When theneurons were treated with DA 10-7～10-4 mol/L prior to the application of GABA for 30 s, 68% (27/40) GABA-activated mem-brane currents were inhibited, whereas DA10-5 inhibited markedly(33.3%) (x±s).
