cGMP POSITIVE CELLS AFTER CEREBRAL ISCHEMIA-REPERFUSION IN THE GERBIL HIPPOCAMPUS AND DENTATE GYRUS
- VernacularTitle:短暂性前脑缺血再灌流后海马本部与齿状回cGMP反应细胞的差异
- Author:
Jingjun ZHANG
;
Zuoli XIA
;
Mingfeng YANG
- Publication Type:Journal Article
- Keywords:
cGMP;
immunohistochemistry;
cerebral ischemia;
astrocytes;
hippocampus;
gerbil
- From:
Chinese Journal of Neuroanatomy
2000;16(3):239-241
- CountryChina
- Language:Chinese
-
Abstract:
The purpose of the present work is to observe cGMP positive cells after cerebral ischemia-reperfusion in the gerbil hip-pocampus. Immunofluorescent methods were used in gerbil hippocampal tissue slices. The results showed that after cerebral is-chemia cGMP synthesis in the CAi-a subfields was increased, cGMP positive cells were distributed mainly in CA1 subfield. Mostof cGMP positive cells were astrocytes. The number of small round cGMP positive cells were increased after recirculation follow-ing ischemia in the dentate gyrus. These results indicate that after cerebral ischemia cGMP synthesis was increased in the CA1-asubfield, It is possible that astrocytes play an important role in the regulation of metabolism in the early stage after ischemia-reperfusion.
