The role of inducible nitric oxide synthase in the regulation of arterial pressure in Dahl salt-sensitive rats
- VernacularTitle:诱导型一氧化氮合酶与Dahl-盐敏感大鼠动脉血压的调节
- Publication Type:Journal Article
- Keywords: Nitric oxide; Blood pressure; Rats
- From: Chinese Journal of Pathophysiology 2000;16(3):207-210
- CountryChina
- Language:Chinese
- Abstract: AIM AND METHODS: To clarify the role of inducible nitric oxide synthase (iNOS) in the hemodynamic regulation of Dahl salt-sensitive (DS) rats,in the present study, we examined the effect of aminoguanidine (AG), a selective inhibitor of iNOS on the pressor response of DS rats to high sodium chloride (NaCl) intake by chronical in vivo hemodynamic experiment, and the effect of NaCl or NaCl plus AG infusion on urinary nitrate (NO-3)/nitrite (NO-2), the end product of nitric oxide (NO), excretion by Greiss Reaction. Furthermore, an iNOS activity assay was also made. RESULTS: The hypertensive effect of high NaCl (8%) infusion was greatly amplified by co-infusion of AG. Administration of high NaCl significantly elevated the iNOS activity of renal tissue including cortex, inner medulla and outer medulla, and greatly increased urinary NO-3/NO-2 excretion. CONCLUSION: Inducible NOS is an important modulator of blood pressure in DS rats under the condition of NaCl-induced hypertension.