Estradiol in inhibition of proliferation of vascular smooth muscle cells after balloon injury
- VernacularTitle:雌二醇抑制动脉球囊损伤后平滑肌细胞增殖
- Author:
Zhisheng ZHAO
;
Congxin HUANG
;
Hong JIANG
;
Teng WANG
;
Jing WANG
;
Gengshan LI
- Publication Type:Journal Article
- Keywords:
estradiol;
neointimal proliferation;
smooth muscle cells;
vascular endothelial injury;
cartoid
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2000;5(3):201-204
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate estradiol inhibition of neointimal proliferation after rat carotid artery balloon injury. Methods Eight to ten-week-old SD rats (male,n=21,female,n=21) were divided into intact control(n=7),gonadectomy control(n=7) and estradiol (n=7, gonadectomy)groups in each sex. Left carotid artery was not injured with 2.0 F PTCA balloon until estradiol was injected for three days. Rats were killed 2 wk after injury. Neointimal areas and media area, ratios of intimal areas/media areas were measured with computer. Results Male neointimal areas and ratios of intimal areas /media areas in estradiol group were less than those in intact control group significantly(all P<0.01) and than those in gonadectomy control group (all P<0.05). Those in female,in estrdiol group were less than those in gonadectomy control group evidently (all P<0.01),and similar to those in intact control group (all P>0.05). Conclusions Estrdiol inhibits neointimal proliferation after the gonadectomy in rats undergoing carotid artery balloon injury.
