Ischaemia preconditioning attenuates hypothermic ischaemia-reperfusion related early graft dysfunction following orthotopic lung transplantation in the rat
- Author:
Xingyi ZHANG
;
Mei SUN
;
Rongyou WANG
- Publication Type:Journal Article
- Keywords:
Orthotopic lung transplantation;
ischaemia preconditioning
- From:
Journal of Jilin University(Medicine Edition)
2000;26(2):162-165
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of ischaemia preconditioning (IP) on function of the transplanted lungs.Methods:Rat orthotopic left lung transplantation (OLT) was performed using the cuff anastomosis technique.The rats were divided into two groups ① CONT (n=16):OLT without IP.② IP (n=15):OLT plus IP.Results:In IP group blood gas exchange and recipient survivals were significantly improved and extravascular water content decreased compared with CONT group.Conclusion:Ischaemia preconditioning not only ameliorates graft injury but inhibits graft dysfunction after OLT.
