EGF、TNF、 SOD levels and hemorrheological changes in patients with diabetic retinopathy
- VernacularTitle:糖尿病视网膜病变患者EGF、TNF、SOD水平和血液流变学改变
- Author:
Donghao LI
;
Chunhui GONG
;
Xueshi WU
;
Min LI
;
Ciyu CHEN
- Publication Type:Journal Article
- Keywords:
diabetic retinopathy;
epithelium growth factor;
tumor necrosis factor;
superoxide dismutase;
hemorrheology
- From:
Recent Advances in Ophthalmology
2000;20(5):350-352
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the change of epithelium growth factor(EGF), tumor necrosis factor (TNF), superoxide dismutese(SOD) and hemorrheology (HL) in patients with diabetic retinopathy.Methods EGF、TNF、SOD levels and HL changes have been measured in 30 NIDDM patients with retinopathy (DR group), 29 NIDDM patients without retinopathy (NDR group), and 29 patients with senile cataract and without diabetes as control (C group). Results The mean levels of EGF、TNF and blood viscosity were significantly higher in both DR and NDR group than those in C group; the mean levels of SOD was significantly lower in both DR and NDR group than that in C group. The EGF、TNF and blood viscosity was significantly higher in proliferative type DR than in background DR; The SOD was significantly lower in proliferative type DR than in background DR.Conclusion The development of diabetic retinopathy is related to the increase of EGF、TNF、blood viscosity and decrease of serum SOD.
