Analysis of the relationship of ET、CGRP、TXB2 and 6-Keto-PGF1α in blood plasma with diabetic retinopathy
- VernacularTitle:糖尿病视网膜病变与血浆中ET、CGRP、TXB2、6-Keto-PGF1α的相关分析
- Author:
Zhandong HUANG
;
Fengkum WANG
;
Jingrong LI
- Publication Type:Journal Article
- Keywords:
Diabetic retinopathy Endothelin Calcitonin gene related peptide
- From:
Chinese Journal of Diabetes
2000;8(6):339-341
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the changes of the four active substances endothelin(ET),calcitonin gene related peptide (CGRP),thromboxane B2(TXB2) and 6-Keto-prostaglandin F1α(6-Keto-PGF1α) in plasma when they acted on each other in the formation and development of diabetic retinopathy.Methods Using the method of radio-immunity,the levels of ET,CGRP,TXB2,6-Keto-PGF1α in plasma were measured in four groups of patients with type 2 diabetes (group 1∶40 cases without retinopathy;group 2∶40 cases with primary retinopathy;group 3.40 cases with hyperplasia type of retinopath;group 4∶40 cases normal controls).Results The results showed that ET increased progressively (P＜0.01) with the prolonging of the duration of DM and the worsening of retina damage、CGRP showed a decreasing tendency (P＜0.05,P＜0.01) in the advanced stage of DM retinopathy.Rectilinear regression analysis showed that the association of ET/CGRP with TXB2/6-Keto-PGF1α became closer with the worsening of deabetic retinopathy (r=0.44,P＜0.05;r=0.596,P＜0.01).Conclusion The four active substances acted on each other in the formation and development of diabetic retinopathy.It had a significent meaning in the initial mechanism of DM,in the development of disease and in the direction of medication usage to understand their relationship.
