Effect of Microinjection of GABA into Parabrachial Nuclei in Rats on Blood Pressure and Heart Rate
- VernacularTitle:大鼠臂旁核内微注射GABA对血压和心率的影响
- Author:
Changjin LIU
;
Limin YANG
;
Chengjun HUANG
- Publication Type:Journal Article
- Keywords:
parabrachial nucleus;
Y-amino butyric acid;
bicuculine;
mean arterial pressure;
heart rate
- From:Acta Medicinae Universitatis Scientiae et Technologiae Huazhong
2000;29(5):391-393
- CountryChina
- Language:Chinese
-
Abstract:
Experiments were carried out in 31 urethane anesthetized, Suxamethonium chloride paralyzed and artificially ventilated rats. The results were as follows: microinjection of γ-amino butyric acid (GABA) into parabrachial nuclei (NPB) markedly decreased the mean arterial pressure (MAP) (P＜0. 001), while the microinjection of bicuculine (Bic) into NPB caused a significant increase in MAP (P＜0. 001). The depressor effect of GABA could be blocked by preinjection of Bic in NPB. The above agents microinjected into NPB had no significant effect on heart rate (P＞0. 05). The results indicated that: (1) GABA in NPB exerts tonic depressor effect; (2) Endogenous GABA in NPB exerts tonic depressor action and takes part in maintenance of normal blood pressure level.
