Changes of Activity of Placental Villus Cytochrome C Oxidase in Pregnant Women with Preeclampsia
- VernacularTitle:妊高征患者胎盘绒毛细胞色素C氧化酶活性的变化
- Author:
Zehua WANG
;
Guanglan ZHANG
- Publication Type:Journal Article
- Keywords:
pregnancy complications,cardiovascular;
hypertension;
cytochrome C oxidase
- From:
Acta Medicinae Universitatis Scientiae et Technologiae Huazhong
2000;29(5):439-441
- CountryChina
- Language:Chinese
-
Abstract:
To explore the role of cytochrome C oxidase (CCO) in the pathogenesis of preeclampsiais, CCO activity was determined in 32 patients with preeclampsia and 26 normotension pregnancy women by the rate of cyanide-sensitive oxidation of reduced cytochrome c using ultraviolet spectrophotometry. The results showed that CCO activity was significantly lower in the preeclampsia group (0. 30±0. 39/min, n=32) than in the control group (0. 73±0. 54/min, n=26), P＜0. 01. The occurrence of IUGR in the preeclampsia group was significantly higher than in the control group (P＜0. 05). It was suggested that the decrease of activity of CCO might interfere with the function of electronic chains, result in the reduction of ATP production, leading to the mitochondria dysfunction and placental dysfunction in preeclampsia patients. Mitochondria dysfunction may be involved in the pathogenesis of preeclampsia.
