Expression and Prognostic Significance of CD44v6 in Advanced Cervical Cancer
- VernacularTitle:中晚期宫颈癌患者CD44v6的表达及其预后价值
- Author:
Huihua XIONG
;
Shiying YU
- Publication Type:Journal Article
- Keywords:
cervical cancer;
adhesion molecule,prognosis
- From:Acta Medicinae Universitatis Scientiae et Technologiae Huazhong
2000;29(5):448-449
- CountryChina
- Language:Chinese
-
Abstract:
The expression of CD44v6 in 105 cases of advanced cervical cancer was detected by using im munohistoehemical method and the relation between adhesion molecule CD44v6 and prognosis in advanced cervical cancer was investigated. The experimental results showed that the lymphocytic infiltration and peritumor reaction of fibrin in the stroma were milder in the patients with CD44v6 positive than those with CD44v6 negative. There were significant reductions in overall and free relapse survival in the patients with CD44v6 positive as compared with those with CD44v6 negative. It was suggested that the expression of CD44v6 might serve as a new indicator for predicting the prognosis of advanced cervical cancer. Tumor cells might interfere with the recognition of the peritumor lymphocyte and reduce the peritumor reaction of fibrin in the stroma through the expression of CD44v6.
