Diagnostic value of serum type IV collagen in hepatic fibrosis
- VernacularTitle:血清IV型胶原在肝纤维化诊断中的意义
- Author:
Xiaowei LI
;
Xinming CHANG
- Publication Type:Journal Article
- Keywords:
hepatic fibrosis;
type IV collagen;
chronic hepatitis;
liver cirrhosis
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
2000;21(5):431-432
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo study the diagnostic value of serum type IV collagen(IV-C) in hepatic fibrosis. MethodsSerum IV-C levels were detected by using radioimmunoassay(RIA) and were compared with serum type Ⅲ procollagen(PCⅢ ) levels in normal controls(NC) and patients with chronic liver diseases. ResultsSerum IV-C and PCⅢ levels in patients with chronic liver diseases were all much higher than those in NC(P < 0.01, totally). Serum IV-C level in severe chronic hepa titis(CH) group was significantly higher than those in mild and median CH groups (P<0.01 total ly), and that in active liver cirrhosis(LC) group was significantly higher than that in static LC group (P＜0.05). There were significant positive correlation between serum IV-C level and serum PcⅢ level both in CH group and in LC group ( in CH γ=0.7023, in LC γ=0. 5878, P＜0. 001).Conclusion Serum IV-C level could reflect the activity of hepatic fibrogenesis.
