Effect of Epidermal Growth Factor and Glutamine-Supplemented Toal Parenteral Nutrition on Gut Barrier and Bacterial Translocation
- VernacularTitle:表皮生长因子、谷氨酰胺强化的全胃肠外营养对肠屏障功能和肠细菌移位的影响
- Author:
Guowei XIA
;
Haian SHI
;
Yakui ZHOU
- Publication Type:Journal Article
- Keywords:
total parenteral nutrition;
epidermal growth factor
- From:
Fudan University Journal of Medical Sciences
2000;27(6):443-445
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To detect the prevention of EGF and GLN on the side effect of TPN. Methods We randomized SD rats into four groups:group A (control),B(STPN),C(TPN+GLN),D(TPN+GLN+EGF).All rats were maintained on their respective diets for 8 days,at which time they were killed and the proximal jejunum was incised for biopsy,the MLN and celiac vein blood were collected for bacterial culture(aerobic culture). Results Group B rat mucosal cell atrophied,DNA and RNA content and plasma cell decreased,the positive rat of MLN bacterial culture was 62.5%.Atrophy in group C alleviated and bacterial translocation rate declined(37.5%).Group D was similar with group A. Conclusions GLN combined with EGF is more effective in protecting gut barrier function and preventing bacterial translocation than GLN alone.
