Role of Ambroxol in Protection of the Decrease of PS in Lung Injury after Thoracotomy
- VernacularTitle:盐酸氨溴索对胸部外科手术致PS下降的保护作用
- Author:
Lijie TAN
;
Yanqing LIU
;
Songtao XU
;
Dehui QIU
- Publication Type:Journal Article
- Keywords:
thoracotomy;
pulmonary surfactant;
ambroxol
- From:
Fudan University Journal of Medical Sciences
2000;27(6):48-487
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To investigate whether thoracotomy can induce lung injury in the operative side and the protection by ambroxol in this procedure. Methods 24 patients with esophageal carcinoma who were performed esophagectomy with anastomosis over the arcus aortae were randomized into 2 groups:an ambroxol group (ambroxol 1 g iv gtt qd×3,preoperatively) and a controlled group without any respiratory medication.General anesthesia by tracheo-cannula combined with continuous epidual anesthesia were used in all the patients.Bilateral broncho-alveolar lavage(BAL) was carried out after intubation preoperatively and before removal of the cannula postoperatively.Total Phospholipid(TPL),Saturated Phosphaytidylcholine(SatPC) and Total protein(TP) in the BALF were measured.The ratio of SatPC/TPL and SatPC/TP represented the activity of PS. Results In the controlled group,SatPC/TPL and SatPC/TP of the left lung(operation side) showed significant difference(P<0.05),compared with the right side(non-operation side).In the ambroxol group,no significant difference of such ratio was showed. Conclusions Thoracotomy can induce lung injury and bring out the decrease of PS and increase of protein exudation in the operative side.Large dose of ambroxol can promote in synthesize and secretion of PS and protect those changes.
