Effects of Polyglycosides of Tripterygium Wilfordii Hook on Inflammation and Immune Suppression
- VernacularTitle:雷公藤多甙的抗炎和免疫抑制作用
- Author:
Hong LI
;
Yongfeng JIA
;
Duan LI
- Publication Type:Journal Article
- Keywords:
polyglycosides of tripterygium wilfordii Hook
- From:
Fudan University Journal of Medical Sciences
2000;27(6):502-505
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To study the anti-inflammatory,anti-allergy and immunosuppressive effect of polyglycosides of tripterygium wilfordii Hook (TⅡ). Methods Animal model of acute and subacute inflammation,adjuvant arthritis,type Ⅳ and Ⅲ allergic reaction were used.Serum haemolysin level,lymphocyte proliferation and T-cell subsets in spleen were tested. Results TⅡ 60,120 mg/kg and pre(prednisone)10 mg/kg had marked inhibitory effect on carrageenine induced swelling,tampon induced granulation and on the prevention of adjuvant arthritis.The delayed type hypersensitivity reaction(type Ⅳ) and arthus reaction (type Ⅲ) was distinctly suppressed.It had a suppressive action on serum haemolysin and lymphocyte proliferation with and without concanavatin A which was dose dependent.In the T-cell subsets:TⅡ 60 mg/kg decreased TS and TⅡ 120 mg/kg inhibited both TS and TH,preacted mainly on TH and rendered the decreased ratio of TH/TS. Conclusions TⅡ has suppressive effect on inflammation,allergic reaction and immune function.
