Effects of Trihexyphenidyl on Monoamine Neurotransmitters in Cerebral Cortex after Subarachnoid Hemorrhage
- VernacularTitle:苯海索对蛛网膜下腔出血后脑皮质单胺递质的影响
- Author:
Qinghe XING
;
Guiqing ZHANG
;
Hongyun JI
;
Yongming WANG
- Publication Type:Journal Article
- Keywords:
subarachnoid hemorrhage;
trihexyphenidyl
- From:
Fudan University Journal of Medical Sciences
2000;27(6):506-508
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To study the effects of trihexyphenidyl (THP) on levels of monoamine neurotransmitters in the cerebral cortex after subarachnoid hemorrhage (SAH). Methods SAH model of rats were used,the levels of norepinephrine (NE),dopamine(DA),5-hydroxytrypatamine (5?HT) and hydroxyindoleacetic acid (5?HIAA) were measured by flurospectrophotometry. Results There was an extensive increase in levels of NE (P<0.01),5?HT (P<0.01) and 5?HIAA (P<0.01) in the cerebral cortex after SAH,DA had a tendency to increase without significance.The increase in levels of NE (P<0.01),5?HT (P<0.01) and 5?HIAA (P<0.05) in the cerebral cortex after SAH could be effectively inhibited by THP. Conclusions There will be a remarkable increase in levels of NE,5HT and 5HIAA in the cerebral cortex after SAH,THP could significantly ameliorate the metabolic disorder of NE and 5HT after SAH
