Immunohistochemical study of related inflammatory cytokines in epiretinal membrane
- VernacularTitle:视网膜前膜内相关炎性细胞因子的免疫组化研究
- Author:
Ping GAO
;
Yannian HUI
;
Jixian MA
;
Wenyong WANG
- Publication Type:Journal Article
- Keywords:
epiretinal membrane;
proliferative vitreoretinopathy;
cytokine;
immunohistochemistry
- From:
Recent Advances in Ophthalmology
2000;20(6):390-392
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression and role of inflammatory cytokines like interleukin-1β(IL-1β)、interleukin-6(IL-6)、interleukin-8(IL-8) and tumor necrosis factor-alpha(TNF-α)in epiretinal membranes(ERM)of eyes with proliferative vitreoretinopathy(PVR).Methods Nineteen epiretinal membranes were obtained from eyes undergoing vitrectomy for retinal detachment complicated with PVR and observed by immunohistochemical methods.Results Expression of IL-1β、IL-6、IL-8 and TNF-α were observed in 9、12、11and 15 membranes respectively, with positive staining mostly in the extracellular matrix of epiretinal membranes. Only one membrane showed positive to IL-6 intracellularly, expression for all the cytokines simultaneously in 4 membranes.Conclusion The findings indicate that cytokine-mediated pathways of inflammation are involved in the pathogenesis of PVR.
