Growth hormone regulate the function of T lymphocytes
- VernacularTitle:生长激素调节T淋巴细胞的功能
- Author:
Hui WANG
;
Jieying DENG
;
Yifan SHI
- Publication Type:Journal Article
- Keywords:
Growth hormone T lymphocyte Cytokine
- From:
Chinese Journal of Immunology
2000;16(9):480-484
- CountryChina
- Language:Chinese
-
Abstract:
To study the effects of growth hormone on function of T lymphocytes. Methods: Tne expression plasmid PcDNA-GHcDNA was constructed,then the plasmids were transfected into Jurkat cells,on the other hand,Jurkat cells were treated with different doses ofrhGH, to investigate the effect of overexpression GH and rhGH on function of T lymphocytes. Results: Overexpression GH could increase the ex-pression of IL-2R(140％) and secretion of IL-2(160％) and IFN-γ( 198% ) in Jurkat cells after PHA activation,but these data were broughtdown by the treatment of GH antibody. rhGH could also enhancer the function of T lymphocytes after PHA activation. Conclusion: These resultssupport the idea that GH is an autocrine and paracrine factor, and can regulate the function of T lymphocytes.
