Antitumor activity and immunoregulatory effect of triterpenes isolated from betulaplatyphylla
- VernacularTitle:白桦三萜类物质的抗肿瘤作用及其对免疫功能的增强效应
- Author:
Wei LI
;
Yah LI
;
Xiongjie JIN
- Publication Type:Journal Article
- Keywords:
Triterpenes isolated from betula platyphylla (TBP) Tumor inhibition rate Immunoregulatory
- From:
Chinese Journal of Immunology
2000;16(9):485-487
- CountryChina
- Language:Chinese
-
Abstract:
To study the antitumor activity and immunoregulatory effect of Triterpenes isolated from Betula Platyphylla (TBP)Methods: Inhihition rate (IR) on tumor growth was determined by the mice with transplantable tumors (melanoma B16, Sarcoma 180, Lewislung carcinoma and Ehrlich ascites cancer), splenocyte proliferation induced by ConA was measured by H-TdR incorporation; cytotoxicity ofmacrophage was observed by 3H-TdR release; activity of TNF and NK cell was determined by dye (natural red)release. Results: IR of 0.80 g/kg and 1.20 g/kg TBP on all of above tumor strains were greater than30％ in vivo. TBPdoes not show significant effect of splenocyte Prolifera-tion and NK cell activity, but significantly promoted the activity of TNF producted by macroghage and splenocyte. TBP also increase the cyto-toxicity of macrophage. Conclusion:TBP shows potent antitumor effect in vivo. Promoting nonspecific immunoactivity is one of the antitumormechanism of TBP.
