Changes of plasma calcitonin gene-related peptide and endothelin levels in patients with pregnancy-induced hypertension
- VernacularTitle:妊高征血浆环核苷酸含量的变化
- Author:
Yanhui ZHAO
;
Lingyun ZHANG
;
Weiyuan ZHANG
- Publication Type:Journal Article
- Keywords:
pregnancy-induced hypertension;
plasma;
cAMP;
cGMP
- From:
Journal of Jilin University(Medicine Edition)
2000;26(6):607-609
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the effect of the plasma cyclic nucleotide in patients with pregnancy-in-duced hypertension. Methods :To observe the level of the plasma cAMP by radio competitive protein bind-ing assay and level of the p lasma cGMP by radioimmunoassay (RIA). Results:The contents of the plasmacAMP and cGMP were significantly higher in PIH group than those in the controls. Plasma cAMP showedthe negative correlation to postpartum MAP. Conclusion:cAMP and cGMP had synergy on antagonizingthe contraction evoked by Ca2+. This was an effective compensatory protective mechanism of PIH.
