Effects of peripheral pain-sensitive substance on the firing rate of pain-related neurons in habenula
- VernacularTitle:外周痛敏物质对缰核痛相关神经元放电频率的影响
- Author:
Min HUANG
;
Guohua LI
;
Xiaojie CAO
;
Shao WANG
- Publication Type:Journal Article
- Keywords:
habenular nucleus (Hb);
discharge;
pain-threshold;
prostaglandin E2 (PGE2);
sympathetic
- From:
Journal of Jilin University(Medicine Edition)
2000;26(6):565-567
- CountryChina
- Language:Chinese
-
Abstract:
Objective:In this experiment we used pain-related neurons of Hb unit discharges recording asa standard to observe the effects of prostaglandin E2 (i. p. ) on Hb unit discharges. Methods :The methodsof unit discharges recording and radiant heat induced tail flick responce were used. Results :The dischargesof pain-excited neurons increased after the addition of PGE2 (i. p. ). The discharges of pain-inhibited neu-rons dec reased after the addition of PGE2(i. p. );PGE2(i. p. ) caused the pain threshold to drop after sym-pathetic nerves were destroyed by 6-OHDA. There were no changes of the pain threshold in undestroyedgroup (P＞0.05). The percentage changes of Hb neurons dropped compared with that of undestroyedgroup (P＜0. 05). Conclusion: The PGE2 could change the discharges of pain-related neurons in Hb, inwhich the sympathetic system might participate in the process.
