Effect of BmK-9-(2) on cardiac sodium channels in Guinea-pig ventricular myocytes
- VernacularTitle:东亚钳蝎毒BmK-9-(2)对豚鼠心室肌细胞钠通道的影响
- Author:
Wenjie ZHANG
;
Wei ZHANG
;
Lijuan LIU
;
Guogan ZHONG
;
Jingyan GE
- Publication Type:Journal Article
- Keywords:
BmK-9-(2);
sodium channels;
patch-clamp
- From:
Journal of Jilin University(Medicine Edition)
2000;26(6):568-570
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of the BmK-9-(2) on the sodium current in guinea-pigventricular myocytes. Methods:The whole cell patch-clamp technique was used. Results:The BmK-9-(2)increased the magnitude of the peak inward sodium current (27 ％) ,peak sodium conductace (17 %) and theprolong time course of sodium channel inactivation (8％) and there was no effects on calcium channels.Conclusion:BmK-9-(2) can activate sodium channel and prolong the inactivated course of myocytes.
