Ambroxol Prevents Premature Infant Pulmenary Hyaline Membrane Disease
- VernacularTitle:沐舒坦预防早产儿肺透明膜病
- Author:
Lei ZHANG
;
Zhongzhi ZHU
;
Haiting TANG
;
Qing SHI
- Publication Type:Journal Article
- Keywords:
premature infant;
hyaline membrane disease;
ambroxol
- From:
Fudan University Journal of Medical Sciences
2000;27(6):509-513
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To evaluate the effects of ambroxol on prevention of premature babies with hyaline membrane disease(HMD) with prenatal corticosteroids. Methods Premature neonates gestational age 26-36 weeks were divided into two groups,receiving:(1) Ambroxol 30 mg/kg through umbilical vein at birth(group A,n=28) and (2) a control group not given ambroxol (group B,n=35).All the babies were exposed prenatally corticosteroids. Results (1) Occurrence rate of HMD in group A was 0%,group B was 11.4%,there was significant difference (P<0.05).(2) Mean fetal age of group A was 32.47+/-4.5 pregnant weeks,group B is 32.86+/-7.1 weeks.No significant difference existed.(3) Different fetal age in gruop B,such as pregnant weeks≤32,33-34,35-36,the HMD rate was separately 28.7%,15.38% and 0%,no case was found in group A.(4) There cases of 12 neonatal asphyxia happened in group B,but none of 6 in group A. Conclusions Definite effect can be received by applying ambroxol to prevent premature infant HMD after delivery on the bases of adenotropin before delivery.
